Journal article
Templated polymer replica nanoparticles to facilitate assessment of material-dependent pharmacokinetics and biodistribution
D Song, J Cui, H Sun, TH Nguyen, S Alcantara, R De Rose, SJ Kent, CJH Porter, F Caruso
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2017
Abstract
Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. In many cases, the chemical nature of the treatments employed to modify the biological interface (for example attachment of hydrophilic polymers or targeting groups) is the focus of attention. However, isolation of the fundamental effects of the materials employed to modify the interface are often confounded by secondary effects imparted by the underlying substrate. Herein, we demonstrate that polymer replica particles templated from degradable mesoporous silica provide a facile means to evaluate the impact of surface modification on the biological interactions of nanomaterials, indep..
View full abstractRelated Projects (2)
Grants
Awarded by Australian Research Council
Funding Acknowledgements
This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). This research was also supported by the ARC under the Australian Laureate Fellowship scheme (FL120100030). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We acknowledge Dr. Junling Guo and Dr. Ka Fung Noi (The University of Melbourne) for helpful discussions and Dr. Edgar H. H. Wong (University of New South Wales) for providing the PHPMA macrocross-linker.